p40 (p63 Delta) (AA 1-50) anticorps

N° du produit ABIN7449374

L’anticorps Souris Monoclonal anti- a été validé pour WB et IHC. Il convient pour détecter dans des échantillons de Humain.

Aperçu rapide pour p40 (p63 Delta) (AA 1-50) anticorps (ABIN7449374)

Antigène: p40 (p63 Delta)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: BC28

Détail du produit

Épitope: AA 1-50

Fonction: Mouse anti-p40 Monoclonal Antibody [BC28]

Immunogène: between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

WB: 17:40:00

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détail du antigène

Antigène: p40 (p63 Delta)

Autre désignation: p40

Sujet: Background: Tumor protein p63 is a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. P63 is an extremely sensitive marker of lung squamous cell carcinoma, but it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types. P40 is a splice isoform of p63 known as DeltaNp63 and has been demonstrated to be highly specific for squamous/basal cells making it is markedly superior to p63 in specificity [adapted from NCBI Entrez Gene (Gene ID: 8626)].

ID gène: 8626

NCBI Accession: NP_003713

UniProt: Q9H3D4